The information contained on this page is provided for educational and informational purposes only and is made available pursuant to Section 5 of DSHEA as “third-party literature.” Any references and articles themselves are not intended to imply and should not be construed as implying that any supplement is to be used to diagnose, treat, cure or prevent any disease.
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Nootropic Nutraceutical
Active Compound
Scientific Reference
The information contained on this page is provided for educational and informational purposes only and is made available pursuant to Section 5 of DSHEA as “third-party literature.” Any references and articles themselves are not intended to imply and should not be construed as implying that any supplement is to be used to diagnose, treat, cure or prevent any disease.
This section lists Nootropic Nutraceuticals, Active Compounds, and Scientific References (linked).
Search content with-in this page:
Vitamin D3
Cholecalciferol
Calcium Orotate
Calcium
Zinc Orotate
Zinc
Tahmasebi K, Amani R, Nazari Z, Ahmadi K, Moazzen S, Mostafavi SA. Association of Mood Disorders with Serum Zinc Concentrations in Adolescent Female Students. Biol Trace Elem Res. 2017 Aug;178(2):180-188. doi: 10.1007/s12011-016-0917-7. Epub 2017 Jan 7. PMID: 28064416. PMID 11739863, PMID 34634109
Lithium Orotate
Lithium
Pacholko AG, Bekar LK. Lithium orotate: A superior option for lithium therapy? Brain Behav. 2021 Aug;11(8):e2262. doi: 10.1002/brb3.2262. Epub 2021 Jul 1. PMID: 34196467; PMCID: PMC8413749.
Chromium Nicotinate Glycinate
Chromium
Li X, Xia X, Jiang B, Yao Y, Ding F, Qin S. Higher serum chromium level may be associated with the presentation of depression in patients with metabolic dysfunction-associated fatty liver disease: evidence from NHANES survey. Front Psychiatry. 2024 Mar 18;15:1330283. doi: 10.3389/fpsyt.2024.1330283. PMID: 38563024; PMCID: PMC10982505. PMID 26311428 PMID 18636317 PMID 22423897
Boron Citrate
Boron
L-selenomethionine
Selenium
Zhou J, Xu H, Huang K. Organoselenium Small Molecules and Chromium(III) Complexes for Intervention in Chronic Low-grade Inflammation and Type 2 Diabetes. Curr Top Med Chem. 2016;16(8):823-34. doi: 10.2174/1568026615666150827094815. PMID: 26311428.
Rhodiola rosea
Rosavins & Salidrosides
Zhang J, Li Z, Song J, Zhou L, Chen X, Ge W, Dong T, Luo Y, Mao T, Li Z, Tan D, Rasmussen LJ, Bohr VA, Tong X, Dai F. Salidroside promotes healthy longevity by interfering with HSP90 activity. Geroscience. 2024 Apr;46(2):1641-1655. doi: 10.1007/s11357-023-00921-3. Epub 2023 Sep 15. PMID: 37713088; PMCID: PMC10828337, PMID 36027482, PMID 37169278
Bacopa monnieri
Bacosides
McPhee GM, Downey LA, Wesnes KA, Stough C. The Neurocognitive Effects of Bacopa monnieri and Cognitive Training on Markers of Brain Microstructure in Healthy Older Adults. Front Aging Neurosci. 2021 Feb 22;13:638109. doi: 10.3389/fnagi.2021.638109. PMID: 33692683; PMCID: PMC7937913, PMID 29676230, PMID 25089244, PMID 26413126, PMID 38671841.
Ashwagandha (Withania somnifera)
Withanolides
Majeed M, Nagabhushanam K, Mundkur L. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2023 Oct 13;102(41):e35521. doi: 10.1097/MD.0000000000035521. PMID: 37832082; PMCID: PMC10578737, PMID 19444606, PMID 39125360, PMID 38931168
Acai (Euterpe oleracea)
Anthocyanins & Flavonoids
Spinelli S, Straface E, Gambardella L, Caruso D, Falliti G, Remigante A, Marino A, Morabito R. Aging Injury Impairs Structural Properties and Cell Signaling in Human Red Blood Cells; Açaì Berry Is a Keystone. Antioxidants (Basel). 2023 Apr 1;12(4):848. doi: 10.3390/antiox12040848. PMID: 37107223; PMCID: PMC10135063, PMID 37109548, PMID 35954235,PMID 34021869
Gynostemma
Gypenoside
Liang G, Lee YZ, Kow ASF, Lee QL, Cheng Lim LW, Yusof R, Tham CL, Ho YC, Lee MT. Neuroprotective effects of Gypenosides: A review on preclinical studies in neuropsychiatric disorders. Eur J Pharmacol. 2024 Sep 5;978:176766. doi: 10.1016/j.ejphar.2024.176766. Epub 2024 Jun 20. PMID: 38908668, PMID 35370734
Saffron
Safranal Crocin/Crocetin
Scuto M, Modafferi S, Rampulla F, Zimbone V, Tomasello M, Spano’ S, Ontario ML, Palmeri A, Trovato Salinaro A, Siracusa R, Di Paola R, Cuzzocrea S, Calabrese EJ, Wenzel U, Calabrese V. Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy. Mech Ageing Dev. 2022 Jul;205:111686. doi: 10.1016/j.mad.2022.111686. Epub 2022 May 21. PMID: 35609733, PMID 29332222, PMID 37484523, PMID 24299602
Ginger (Zingiber officinale)
Zinzerone
Ginger (Zingiber officinale)
Gingerols
Shen CL, Wang R, Yakhnitsa V, Santos JM, Watson C, Kiritoshi T, Ji G, Hamood AN, Neugebauer V. Gingerol-Enriched Ginger Supplementation Mitigates Neuropathic Pain via Mitigating Intestinal Permeability and Neuroinflammation: Gut-Brain Connection. Front Pharmacol. 2022 Jul 8;13:912609. doi: 10.3389/fphar.2022.912609. PMID: 35873544; PMCID: PMC9305072.
Ancient Seabed
72 Trace Minerals
Lu CH, Ou HC, Day CH, Chen HI, Pai PY, Lee CY, Chen RJ, Chang RL, Padma Viswanadha V, Hsieh DJ, Huang CY. Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFα signaling pathways. Environ Toxicol. 2020 Apr;35(4):468-477. doi: 10.1002/tox.22882. Epub 2019 Dec 3. PMID: 31794124.
Fulvic Minerals
Fulvates, Humic
Berberis vulgaris
Berberine
Gong H, Xia Y, Jing G, Yuan M, Zhou H, Wu D, Zuo J, Lei C, Aidebaike D, Wu X, Song X. Berberine alleviates neuroinflammation by downregulating NFκB/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation. Int Immunopharmacol. 2024 May 30;133:112036. doi: 10.1016/j.intimp.2024.112036. Epub 2024 Apr 18. PMID: 38640713, PMID 38358731
Apple cider vinegar (Organic)
Chlorogenic Acid & Polyphenols
Tripathi S, Kumari U, Mitra Mazumder P. Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers. J Food Biochem. 2020 Dec;44(12):e13504. doi: 10.1111/jfbc.13504. Epub 2020 Oct 20. PMID: 33084094.